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GSH is a cofactor and substrate for GPX4 and is required for the lipid repair function of this enzyme

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Pillar 1: Activity (aerobic + resistance + daily movement) Physical activity improves insulin sensitivity through several mechanisms at once: increased glucose uptake (including non-insulin-mediated uptake), improved muscle insulin signalling, reduced intramuscular lipid burden (DAGs), improved hepatic insulin sensitivity, and improved appetite regulation via brain signalling