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Efficacy and tolerability of tirzepatide, a dual glucose-dependent insulinotropic peptide and glucagon-like peptide-1 receptor agonist in patients with type 2 diabetes: a 12-week, randomized, double-blind, placebo-controlled study to evaluate different dose-escalation regimens

It is due to an autoimmune disease

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The histidine residue serves as the primary copper-binding site through its imidazole ring, creating a stable square-planar copper(II) complex with the amino terminal and adjacent peptide nitrogen atoms