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Contributing factors for T1D pathogenesis, includes genetic factors (HLA, Insulin-VNTR, CTLA-4, PTPN22, AIRE, FoxP3, STAT3, IFIH1, HIP14, ERBB3), epigenetic factors, environmental factors (viruses like rubella and enteroviruses), diet (cereals, cows milk, vitamin-D, and omega-3 fatty acids), gut microbiota, and immunologic factors (Paschou et al., 2018)

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It often appears during dose escalation weeks

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Therefore, we have emphasized the crucial role of the CS and its fine-tuned regulation, which is both enzymatic- and miRNA-dependent, as the primary factor in metabolic cancer flexibility