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G) Bar graph representing an increase in the number of spines following treatment with vehicle, Nlel-AnglV or Dihexa, ensuring health of the neurons (***=P 0.05

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Similarly, polymorphisms in genes such as UGT1A1 (irinotecan metabolism) and CYP3A4/CYP3A5 (TKI metabolism) can alter plasma drug concentrations, leading to increased toxicity or therapeutic failure

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not for self-administration