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This increases the production of nitric oxide (NO), a potent vasodilator and signaling molecule that enhances blood flow and vessel permeability, further supporting tissue repair

Huang L, Liu Y, Yu L, Cheng A, Cao J, Wang R

549 The reactive astrocytes can promote excitotoxic injury of motor neurons by producing nitric oxide and peroxynitrite, which cause mitochondrial damage and apoptosis in cultured neurons, decreasing glutamate transport, releasing pro-apoptotic mediators selectively toxic to motor neurons