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172 In an uncontrolled trial in 30 symptomatic postmenopausal women, taking 100 mg sage extract daily for four weeks reduced the severity of hot flashes, night sweats, panic, and fatigue, and improved concentration

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And presumably evolutionarily our body doesn't like being starved and we're essentially just starving ourselves

[16] Based on these observations, the potential of glutathione in management of melasma and hyperpigmentation seems plausible